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首页  >  酶联免疫试剂盒  >  Mouse Mical3 ELISA Kit
Mical3 (基因名), [F-actin]-monooxygenase MICAL3 (蛋白名), MICA3_MOUSE.
产品名称:

Mouse Mical3/ [F-actin]-monooxygenase MICAL3 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Molecule interacting with CasL protein 3, MICAL-3, Kiaa0819, Kiaa1364

检测方法:
ELISA
特异性:
Natural and recombinant mouse [F-actin]-monooxygenase MICAL3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Mical3 ELISA Kit
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Mouse Mical3 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A can bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively. Interacts with ERC1 and RAB8A; may bridge ERC1 with RAB8A. Interacts with KIF23 and ERC1; enhances the interaction between KIF23 and ERC1. Interacts with NINL.


功能:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.


亚细胞位置:
Cytoplasm Cytoplasm Cell cortex Cytoplasm Cytoskeleton Nucleus Midbody Cytoplasm Cytoskeleton Spindle Cytoplasm Cytoskeleton Cilium basal body Mainly localizes in the nucleus.


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