MICAL3 (GeneName), [F-actin]-monooxygenase MICAL3 (ProteinName), MICA3_HUMAN.
Human MICAL3/ [F-actin]-monooxygenase MICAL3 ELISA Kit
Molecule interacting with CasL protein 3, MICAL-3, KIAA0819, KIAA1364
Natural and recombinant human [F-actin]-monooxygenase MICAL3
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A can bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively. Interacts with ERC1 and RAB8A; may bridge ERC1 with RAB8A. Interacts with KIF23 and ERC1; enhances the interaction between KIF23 and ERC1. Interacts with NINL isoform 2.
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and plays a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission.
Cytoplasm Cytoplasm Cell cortex Cytoplasm Cytoskeleton Nucleus Midbody Cytoplasm Cytoskeleton Spindle Cytoplasm Cytoskeleton Cilium basal body Mainly localizes in the nucleus.
MEERKHETMN | PAHVLFDRFV | QATTCKGTLK | AFQELCDHLE | LKPKDYRSFY |
HKLKSKLNYW | KAKALWAKL | DKRGSHKDYK | KGKACTNTKC | LIIGAGPCGL |
RTAIDLSLLG | AKVVVIEKRD | A FSRNNVLH | LWPFTIHDLR | GLGAKKFYGK |
FCAGAIDHIS | IRQLQLILLK | VALILGIEIH | VN VEFQGLI | QPPEDQENER |
IGWRALVHPK | THPVSEYEFE | VIIGGDGRRN | TLEGFRRKEF | RGK LAIAIT |
ANFINRNTTA | EAKVEEISGV | AFIFNQKFFQ | ELREATGIDL | ENIVYYKDDT |
HYFV MTAKK | QSLLDKGVIL | HDYADTELLL | SRENVDQEAL | LSYAREAADF |
STQQQLPSLD | FAINH YGQP | DVAMFDFTCM | YASENAALVR | EQNGHQLLVA |
LVGDSLLEPF | WPMGTGIARG | FLAAMD SAW | MVRSWSLGTS | PLEVLAERES |
IYRLLPQTTP | ENVSKNFSQY | SIDPVTRYPN | INVNFLR PS | QVRHLYDTGE |
TKDIHLEMES | LVNSRTTPKL | TRNESVARSS | KLLGWCQRQT | DGYAGVNV T |
DLTMSWKSGL | ALCAIIHRYR | PDLIDFDSLD | EQNVEKNNQL | AFDIAEKELG |
ISPIMTGKE | MASVGEPDKL | SMVMYLTQFY | EMFKDSLPSS | DTLDLNAEEK |
AVLIASTRSP | ISFLSKLGQT | ISRKRSPKD | KKEKDLDGAG | KRRKTSQSEE |
EEAPRGHRGE | RPTLVSTLTD | RRMDVAVGNQ | N KVKYMATQ | LLAKFEENAP |
AQSIGIRRQG | SMKKEFPQNL | GGSDTCYFCQ | KRVYVMERLS | AE GKFFHRS |
CFKCEYCATT | LRLSAYAYDI | EDGKFYCKPH | YCYRLSGYAQ | RKRPAVAPLS |
GKE AKGPLQ | DGATTDANGR | ANAVASSTER | TPGSGVNGLE | EPSIAKRLRG |
TPERIELENY | RLSL RQAEA | LQEVPEETQA | EHNLSSVLDT | GAEEDVASSS |
SESEMEEEGE | EEEEEPRLPP | SDLGG VPWK | EAVRIHALLK | GKSEEELEAS |
KSFGPGNEEE | EEEEEEYEEE | EEEDYDEEEE | ESSEAG NQR | LQQVMHAADP |
LEIQADVHWT | HIREREEEER | MAPASESSAS | GAPLDENDLE | EDVDSEP AE |
IEGEAAEDGD | PGDTGAELDD | DQHWSDSPSD | ADRELRLPCP | AEGEAELELR |
VSEDEEKL P | ASPKHQERGP | SQATSPIRSP | QESALLFIPV | HSPSTEGPQL |
PPVPAATQEK | SPEERLFPE | PLLPKEKPKA | DAPSDLKAVH | SPIRSQPVTL |
PEARTPVSPG | SPQPQPPVAA | STPPPSPLPI | CSQPQPSTE | ATVPSPTQSP |
IRFQPAPAKT | STPLAPLPVQ | SQSDTKDRLG | SPLAVDEALR | R SDLVEEFW |
MKSAEIRRSL | GLTPVDRSKG | PEPSFPTPAF | RPVSLKSYSV | EKSPQDEGLH |
LL KPLSIPK | RLGLPKPEGE | PLSLPTPRSP | SDRELRSAQE | ERRELSSSSG |
LGLHGSSSNM | KTL GSQSFN | TSDSAMLTPP | SSPPPPPPPG | EEPATLRRKL |
REAEPNASVV | PPPLPATWMR | PPRE PAQPP | REEVRKSFVE | SVEEIPFADD |
VEDTYDDKTE | DSSLQEKFFT | PPSCWPRPEK | PRHPP LAKE | NGRLPALEGT |
LQPQKRGLPL | VSAEAKELAE | ERMRAREKSV | KSQALRDAMA | RQLSRM QQM |
ELASGAPRPR | KASSAPSQGK | ERRPDSPTRP | TLRGSEEPTL | KHEATSEEVL |
SPPSDSG GP | DGSFTSSEGS | SGKSKKRSSL | FSPRRNKKEK | KSKGEGRPPE |
KPSSNLLEEA | AAKPKSLW K | SVFSGYKKDK | KKKADDKSCP | STPSSGATVD |
SGKHRVLPVV | RAELQLRRQL | SFSEDSDLS | SDDVLEKSSQ | KSRREPRTYT |
EEELNAKLTR | RVQKAARRQA | KQEELKRLHR | AQIIQRQLQQ | VEERQRRLE |
ERGVAVEKAL | RGEAGMGKKD | DPKLMQEWFK | LVQEKNAMVR | YESELMIFAR |
E LELEDRQS | RLQQELRERM | AVEDHLKTEE | ELSEEKQILN | EMLEVVEQRD |
SLVALLEEQR | LR EREEDKD | LEAAMLSKGF | SLNWS
This product has not yet been referenced specifically in any publications.
"MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion."
"MICAL3 Flavoprotein Monooxygenase Forms a Complex with Centralspindlin and Regulates Cytokinesis."
"The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking."
"Redox modification of nuclear actin by MICAL-2 regulates SRF signaling."
"Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers."
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