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Mical1 (GeneName), [F-actin]-monooxygenase MICAL1 (ProteinName), MICA1_MOUSE.
Product Name:

Mouse Mical1/ [F-actin]-monooxygenase MICAL1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Molecule interacting with CasL protein 1, MICAL-1, NEDD9-interacting protein with calponin homology and LIM domains, Mical, Nical

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse [F-actin]-monooxygenase MICAL1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Mical1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously (By similarity). Interacts with STK38 and STK38L.


Function:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking.


Subcellular Location:
Cytoplasm Cytoplasm Cytoskeleton


This product has not yet been referenced specifically in any publications.

[1].
"MICAL, a novel CasL interacting molecule, associates with vimentin."

[2].
"Oxidation of F-actin controls the terminal steps of cytokinesis."

[3].
"Properties and catalytic activities of MICAL1, the flavoenzyme involved in cytoskeleton dynamics, and modulation by its CH, LIM and C-terminal domains."

[4].
"Redox modification of nuclear actin by MICAL-2 regulates SRF signaling."

[5].
"Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1."

[6].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[7].
"Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein."

[8].
"Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain."

[9].
"Solution structure of calponin homology domain of Human MICAL-1."

[10].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
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