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首页  >  酶联免疫试剂盒  >  Human MICAL1 ELISA Kit
MICAL1 (基因名), [F-actin]-monooxygenase MICAL1 (蛋白名), MICA1_HUMAN.
产品名称:

Human MICAL1/ [F-actin]-monooxygenase MICAL1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Molecule interacting with CasL protein 1, MICAL-1, NEDD9-interacting protein with calponin homology and LIM domains, MICAL, NICAL

检测方法:
ELISA
特异性:
Natural and recombinant human [F-actin]-monooxygenase MICAL1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MICAL1 ELISA Kit
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Human MICAL1 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with STK38 and STK38L (By similarity). Interacts with RAB1B, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B is of low affinity compared to other Rab proteins; at least in case of RAB8A and RAB10 can bind 2 molecules of the Rab proteins simultaneously; ternary complex formation of RAB8A, RAB13 and MICAL1 is possible. Associates with the SH3 domain of NEDD9. Interacts with VIM and PLXNA3. Interacts with RAB1B.


功能:
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.


亚细胞位置:
Cytoplasm Cytoplasm Cytoskeleton Midbody Accumulates transiently at the abscission site before abscission occurs.


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