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Immt (GeneName), MICOS complex subunit Mic60 (ProteinName), MIC60_RAT.
Product Name:

Rat Immt/ MICOS complex subunit Mic60 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mitochondrial inner membrane protein, Mitofilin, Mic60

Detection Method:
ELISA
Specificity:
Natural and recombinant rat MICOS complex subunit Mic60
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Epigenetics
Rat Immt ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Found in a complex with CHCHD3/MIC19 and SAMM50 termed mitochondrial intermembrane space bridging (MIB) complex. Interacts with HSPA1A/HSPA1B and OPA1, preferentially with the soluble OPA1 form. Interacts with QIL1/MIC13, MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, SAMM50 and TMEM11. Interacts with APOO/MIC23/MIC26 and APOOL/MIC27.


Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Subcellular Location:
Mitochondrion inner membrane Single-pass membrane protein Mitochondrion


This product has not yet been referenced specifically in any publications.

[1].
"Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms."

[2].
"A novel human gene that is preferentially transcribed in heart muscle."

[3].
"QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."

[4].
"Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits."

[5].
"The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."

[6].
"MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."

[7].
"CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology."

[8].
"ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function."

[9].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[10].
"Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking."
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