APOOL (GeneName), MICOS complex subunit MIC27 (ProteinName), MIC27_HUMAN.
Human APOOL/ MICOS complex subunit MIC27 ELISA Kit
Apolipoprotein O-like, Protein FAM121A, CXorf33, FAM121A, MIC27, UNQ8193/PRO23204
Natural and recombinant human MICOS complex subunit MIC27
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex (PubMed:25764979, PubMed:25781180, PubMed:23704930, PubMed:25764979, PubMed:25781180, PubMed:25997101). The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1, MTX2 and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. Interacts with MINOS1/MIC10, IMMT/MIC60 and APOO/MIC23/MIC26 (PubMed:25764979, PubMed:25781180, PubMed:23704930, PubMed:25764979, PubMed:25781180, PubMed:25997101).
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979).
Mitochondrion inner membrane Multi-pass membrane protein Mitochondrion
MAAIRMGKLT | TMPAGLIYAS | VSVHAAKQEE | SKKQLVKPEQ | LPIYTAPPLQ |
SKYVEEQPGH | LQMGFASIRT | ATGCYIGWCK | GVYVFVKNGI | MDTVQFGKDA |
YVYLKNPPRD | FLPKMGVITV | SGLAGLVSAR | KGSKFKKITY | PLGLATLGAT |
VCYPVQSVII | AKVTAKKVYA | TSQQIFGAVK | SLWTKSSKEE | SLPKPKEKTK |
LGSSSEIEVP | AKTTHVLKHS | VPLPTELSSE | AKTKSESTSG | ATQFMPDPKL |
MDHGQSHPED | IDMYSTRS
This product has not yet been referenced specifically in any publications.
"APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complex determining cristae morphology in mammalian mitochondria."
"The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions."
"Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits."
"QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology."
"The DNA sequence of the human X chromosome."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
"Mapping the Genetic Landscape of Human Cells."
"Architecture of the human interactome defines protein communities and disease networks."
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."
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