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MIB2 (GeneName), E3 ubiquitin-protein ligase MIB2 (ProteinName), MIB2_HUMAN.
Product Name:

Human MIB2/ E3 ubiquitin-protein ligase MIB2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mind bomb homolog 2, Novel zinc finger protein, Novelzin, Putative NF-kappa-B-activating protein 002N, RING-type E3 ubiquitin transferase MIB2, Skeletrophin, Zinc finger ZZ type with ankyrin repeat domain protein 1, SKD, ZZANK1

Detection Method:
ELISA
Specificity:
Natural and recombinant human E3 ubiquitin-protein ligase MIB2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MIB2 ELISA Kit
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Human MIB2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with actin monomer.


Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.


Subcellular Location:
Cytoplasm Endosome Colocalizes with endosomal compartments.


This product has not yet been referenced specifically in any publications.

[1].
"Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."

[2].
"Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma."

[3].
"A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion."

[4].
"Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma."

[5].
"Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma."

[6].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Architecture of the human interactome defines protein communities and disease networks."

[9].
"MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation/non-compaction and are associated with Ménétrier-like gastropathy."

[10].
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."
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