MIB1 (GeneName), E3 ubiquitin-protein ligase MIB1 (ProteinName), MIB1_HUMAN.
Human MIB1/ E3 ubiquitin-protein ligase MIB1 ELISA Kit
DAPK-interacting protein 1, DIP-1, Mind bomb homolog 1, RING-type E3 ubiquitin transferase MIB1, Zinc finger ZZ type with ankyrin repeat domain protein 2, DIP1, KIAA1323, ZZANK2
Natural and recombinant human E3 ubiquitin-protein ligase MIB1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with CEP131 and PCM1.
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.
Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriolar satellite Cell membrane Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
MSNSRNNRVM | VEGVGARVVR | GPDWKWGKQD | GGEGHVGTVR | SFESPEEVVV |
VWDNGTAANY | RCSGAYDLRI | LDSAPTGIKH | DGTMCDTCRQ | QPIIGIRWKC |
AECTNYDLCT | VCYHGDKHHL | RHRFYRITTP | GSERVLLESR | RKSKKITARG |
IFAGARVVRG | VDWQWEDQDG | GNGRRGKVTE | IQDWSASSPH | SAAYVLWDNG |
AKNLYRVGFE | GMSDLKCVQD | AKGGSFYRDH | CPVLGEQNGN | RNPGGLQIGD |
LVNIDLDLEI | VQSLQHGHGG | WTDGMFETLT | TTGTVCGIDE | DHDIVVQYPS |
GNRWTFNPAV | LTKANIVRSG | DAAQGAEGGT | SQFQVGDLVQ | VCYDLERIKL |
LQRGHGEWAE | AMLPTLGKVG | RVQQIYSDSD | LKVEVCGTSW | TYNPAAVSKV |
ASAGSAISNA | SGERLSQLLK | KLFETQESGD | LNEELVKAAA | NGDVAKVEDL |
LKRPDVDVNG | QCAGHTAMQA | ASQNGHVDIL | KLLLKQNVDV | EAEDKDGDRA |
VHHAAFGDEG | AVIEVLHRGS | ADLNARNKRR | QTPLHIAVNK | GHLQVVKTLL |
DFGCHPSLQD | SEGDTPLHDA | ISKKRDDILA | VLLEAGADVT | ITNNNGFNAL |
HHAALRGNPS | AMRVLLSKLP | RPWIVDEKKD | DGYTALHLAA | LNNHVEVAEL |
LVHQGNANLD | IQNVNQQTAL | HLAVERQHTQ | IVRLLVRAGA | KLDIQDKDGD |
TPLHEALRHH | TLSQLRQLQD | MQDVGKVDAA | WEPSKNTLIM | GLGTQGAEKK |
SAASIACFLA | ANGADLSIRN | KKGQSPLDLC | PDPNLCKALA | KCHKEKVSGQ |
VGSRSPSMIS | NDSETLEECM | VCSDMKRDTL | FGPCGHIATC | SLCSPRVKKC |
LICKEQVQSR | TKIEECVVCS | DKKAAVLFQP | CGHMCACENC | ANLMKKCVQC |
RAVVERRVPF | IMCCGGKSSE | DATDDISSGN | IPVLQKDKDN | TNVNADVQKL |
QQQLQDIKEQ | TMCPVCLDRL | KNMIFLCGHG | TCQLCGDRMS | ECPICRKAIE |
This product has not yet been referenced specifically in any publications.
"A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis."
"Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy."
"Mapping a dynamic innate immunity protein interaction network regulating type I interferon production."
"Mind bomb 1 regulation of cFLIP interactions."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Death-associated protein kinase expression in human temporal lobe epilepsy."
"Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta."
"A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK."
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."
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