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首页  >  酶联免疫试剂盒  >  Mouse Chchd4 ELISA Kit
Chchd4 (基因名), Mitochondrial intermembrane space import and assembly protein 40 (蛋白名), MIA40_MOUSE.
产品名称:

Mouse Chchd4/ Mitochondrial intermembrane space import and assembly protein 40 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Coiled-coil-helix-coiled-coil-helix domain-containing protein 4, Mia40

检测方法:
ELISA
特异性:
Natural and recombinant mouse Mitochondrial intermembrane space import and assembly protein 40
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Chchd4 ELISA Kit
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Mouse Chchd4 ELISA Kit
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产品说明书


通用注释


亚单元:
Monomer. Can form homooligomers. Interacts with GFER and forms transient disulfide bonds with GFER. Interacts with MICU1.


功能:
Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake.


亚细胞位置:
Mitochondrion intermembrane space


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