MIF4GD (GeneName), MIF4G domain-containing protein (ProteinName), MI4GD_BOVIN.
Bovine MIF4GD/ MIF4G domain-containing protein ELISA Kit
Natural and recombinant bovine MIF4G domain-containing protein
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with EIF4G1, EIF4G2 and SLBP; probably tethered by SLBP to the 3'-end of mRNAs ending with the histone stem-loop, it also interacts with EIF4G1 which is bound to their 5'-end.
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
MGEPSKEEYK | IQCFDAETQQ | LLKTALKDPG | AVDLEKVANV | IVDHSLQDSV |
FSKEAGRMCY | AIIQAESKQA | GQSVFRRGLL | NRLQQEYQTR | EQLRARSLQG |
WVCYVTFICN | IFDYLRVNNM | PMMALVNPVY | DCLFRLAQPD | SLSKEEEVDC |
LVLQLHRVGE | QLEKMNGQRM | DELFVLIRDG | FLLPAGLSSL | AQLLLLEIIE |
FRAAGWKTTP | AAHKYYYSEV | SD
This product has not yet been referenced specifically in any publications.
"SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein."
"INT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation."
"Architecture of the human interactome defines protein communities and disease networks."
"Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells."
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
"An inter-species protein-protein interaction network across vast evolutionary distance."
"Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor."
"Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
"A human interactome in three quantitative dimensions organized by stoichiometries and abundances."
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