Mgrn1 (GeneName), E3 ubiquitin-protein ligase MGRN1 (ProteinName), MGRN1_MOUSE.
Mouse Mgrn1/ E3 ubiquitin-protein ligase MGRN1 ELISA Kit
Mahogunin RING finger protein 1, RING-type E3 ubiquitin transferase MGRN1, Kiaa0544
Natural and recombinant mouse E3 ubiquitin-protein ligase MGRN1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MC1R and MC4R (By similarity). Interacts with TSG101. Interacts with mislocalized cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement.
E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
Isoform 5 Cytoplasm Nucleus In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli.
MGSILSRRIA | GVEDIDIQAN | SAYRYPPKSG | NYFASHFFMG | GEKFDTPHPE |
GYLFGENMDL | NFLGSRPVQF | PYVTPAPHEP | VKTLRSLVNI | RKDSLRLVRY |
KEDADSPTED | GEKPRVLYSL | EFTFDADARV | AITIYCQAVE | ELVNGVAVYS |
CKNPSLQSET | VHYKRGVSQQ | FSLPSFKIDF | SEWKDDELNF | DLDRGVFPVV |
IQAVVDEGDV | VEVTGHAHVL | LAAFEKHVDG | SFSVKPLKQK | QIVDRVSYLL |
QEIYGIENKN | NQETKPSDDE | NSDNSSECVV | CLSDLRDTLI | LPCRHLCLCT |
SCADTLRYQA | NNCPICRLPF | RALLQIRAVR | KKPGALSPIS | FSPVLAQSVD |
HDEHSSSDSI | PPGYEPISLL | EALNGLRAVS | PAIPSAPLYE | EITYSGISDG |
LSQASCPLAG | LDRIMESGLQ | KGKTQSKSPD | STLRSPSFPI | HEEDEEKLSE |
DSDAPLPPSG | VELVLRESSS | PESFGTEEGD | EPSLKQGSRV | PSIDDVLQDG |
SPQHHGCSQP | VPPADIYLPA | LGPESCSVGI | EE
This product has not yet been referenced specifically in any publications.
"Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas."
"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Pigmentation-related genes and their implication in malignant melanoma susceptibility."
"Abnormal regulation of TSG101 in mice with spongiform neurodegeneration."
"Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase."
"Architecture of the human interactome defines protein communities and disease networks."
"Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing."
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