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Mgrn1 (基因名), E3 ubiquitin-protein ligase MGRN1 (蛋白名), MGRN1_MOUSE.
产品名称:

Mouse Mgrn1/ E3 ubiquitin-protein ligase MGRN1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mahogunin RING finger protein 1, RING-type E3 ubiquitin transferase MGRN1, Kiaa0544

检测方法:
ELISA
特异性:
Natural and recombinant mouse E3 ubiquitin-protein ligase MGRN1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Mgrn1 ELISA Kit
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Mouse Mgrn1 ELISA Kit
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通用注释


亚单元:
Interacts with MC1R and MC4R (By similarity). Interacts with TSG101. Interacts with mislocalized cytosolically exposed PRNP; this interaction alters MGRN1 subcellular location and causes lysosomal enlargement.


功能:
E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.


亚细胞位置:
Isoform 5 Cytoplasm Nucleus In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli.


该产品尚未在任何出版物中被引用。
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