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Magoh (GeneName), Protein mago nashi homolog (ProteinName), MGN_RAT.
Product Name:

Rat Magoh/ Protein mago nashi homolog ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mago-nashi-like proliferation-associated protein

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Protein mago nashi homolog
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat Magoh ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Heterodimer with RBM8A. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A. Interacts with PYM1; the interaction is direct and dissociates the EJC from spliced mRNAs. Identified in the spliceosome C complex.


Function:
Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.


Subcellular Location:
Nucleus Nucleus speckle Cytoplasm Detected in granule-like structures in the dendroplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles (By similarity).


This product has not yet been referenced specifically in any publications.

[1].
"The mammalian homologue of mago nashi encodes a serum-inducible protein."

[2].
"MAGOH interacts with a novel RNA-binding protein."

[3].
"Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators."

[4].
"Disassembly of exon junction complexes by PYM."

[5].
"PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs."

[6].
"The DNA sequence and biological annotation of human chromosome 1."

[7].
"The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA."

[8].
"Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA."

[9].
"The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity."

[10].
"Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements."
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