MGMT (GeneName), Methylated-DNA--protein-cysteine methyltransferase (ProteinName), MGMT_CANLF.
Dog MGMT/ Methylated-DNA--protein-cysteine methyltransferase ELISA Kit
6-O-methylguanine-DNA methyltransferase, MGMT, O-6-methylguanine-DNA-alkyltransferase
Natural and recombinant dog Methylated-DNA--protein-cysteine methyltransferase
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
MDKACKMRYK | TMDSPLGKIE | ISGCAQGLHE | IRLHDRKTPD | PGPAEAPAPP |
ELLGCPEEMT | EPLVQCVAWL | DAYFREPSVL | PGLPLPAIHH | PIFQRGSFTA |
RVLRKLLELV | KFGDTVSYQQ | LAALAGNPKA | ARAVGGAMRS | NPVPILIPCH |
RVVCSSGAMG | NYTGGLATKE | WLLAHEGRLA | GKPTYPGGSY | LAGTRRGALG |
GTPSPHPAGR | DGCVRE
This product has not yet been referenced specifically in any publications.
"Polymorphisms of the DNA repair gene MGMT and risk and progression of head and neck cancer."
"MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa."
"Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians."
"Association between MGMT promoter hypermethylation and p53 mutation in glioblastoma."
"High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations."
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