MGAT3 (GeneName), Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (ProteinName), MGAT3_HUMAN.
Human MGAT3/ Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase ELISA Kit
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III, GNT-III, GGNT3
Natural and recombinant human Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.
Golgi apparatus membrane Single-pass type II membrane protein
MKMRRYKLFL | MFCMAGLCLI | SFLHFFKTLS | YVTFPRELAS | LSPNLVSSFF |
WNNAPVTPQA | SPEPGGPDLL | RTPLYSHSPL | LQPLPPSKAA | EELHRVDLVL |
PEDTTEYFVR | TKAGGVCFKP | GTKMLERPPP | GRPEEKPEGA | NGSSARRPPR |
YLLSARERTG | GRGARRKWVE | CVCLPGWHGP | SCGVPTVVQY | SNLPTKERLV |
PREVPRRVIN | AINVNHEFDL | LDVRFHELGD | VVDAFVVCES | NFTAYGEPRP |
LKFREMLTNG | TFEYIRHKVL | YVFLDHFPPG | GRQDGWIADD | YLRTFLTQDG |
VSRLRNLRPD | DVFIIDDADE | IPARDGVLFL | KLYDGWTEPF | AFHMRKSLYG |
FFWKQPGTLE | VVSGCTVDML | QAVYGLDGIR | LRRRQYYTMP | NFRQYENRTG |
HILVQWSLGS | PLHFAGWHCS | WCFTPEGIYF | KLVSAQNGDF | PRWGDYEDKR |
DLNYIRGLIR | TGGWFDGTQQ | EYPPADPSEH | MYAPKYLLKN | YDRFHYLLDN |
PYQEPRSTAA | GGWRHRGPEG | RPPARGKLDE | AEV
This product has not yet been referenced specifically in any publications.
"cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III)."
"Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease."
"An N-glycosylation site on the beta-propeller domain of the integrin alpha5 subunit plays key roles in both its function and site-specific modification by beta1,4-N-acetylglucosaminyltransferase III."
"The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin."
"Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin."
"A genome annotation-driven approach to cloning the human ORFeome."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration."
"Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells."
"Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus."
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