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Mga (GeneName), MAX gene-associated protein (ProteinName), MGAP_MOUSE.
Product Name:

Mouse Mga/ MAX gene-associated protein ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Kiaa4252

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse MAX gene-associated protein
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Mga ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11 (By similarity). Interacts with MAX. Requires heterodimerization with MAX for E-box binding.


Function:
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF."

[2].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[3].
"Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif."

[4].
"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."

[5].
"Architecture of the human interactome defines protein communities and disease networks."

[6].
"Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis."

[7].
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."

[8].
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."

[9].
"Somatic mutation of a candidate tumour suppressor MGA gene and its mutational heterogeneity in colorectal cancers."

[10].
"Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development."
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