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MGA (基因名), MAX gene-associated protein (蛋白名), MGAP_HUMAN.
产品名称:

Human MGA/ MAX gene-associated protein ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

MAX dimerization protein 5, KIAA0518, MAD5

检测方法:
ELISA
特异性:
Natural and recombinant human MAX gene-associated protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human MGA ELISA Kit
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Human MGA ELISA Kit
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产品说明书
在线询价


通用注释


亚单元:
Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11.


功能:
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.


亚细胞位置:
Nucleus


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