MFSD2B (GeneName), Major facilitator superfamily domain-containing protein 2B (ProteinName), MFS2B_HUMAN.
Human MFSD2B/ Major facilitator superfamily domain-containing protein 2B ELISA Kit
Natural and recombinant human Major facilitator superfamily domain-containing protein 2B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Does not transport lysophosphatidylcholine (LPC) (By similarity).
Cell membrane Multi-pass membrane protein Localizes to the cell membrane and intracellular membranes.
MAAPPAPAAK | GSPQPEPHAP | EPGPGSAKRG | REDSRAGRLS | FCTKVCYGIG |
GVPNQIASSA | TAFYLQLFL | LDIAQIPAAQ | VSLVLFGGKV | SGAAADPVAG |
FFINRSQRTG | SGRLMPWVLG | C TPFIALAY | FFLWFLPPFT | SLRGLWYTTF |
YCLFQALATF | FQVPYTALTM | LLTPCPRERD | SA TAYRMTV | EMAGTLMGAT |
VHGLIVSGAH | RPHRCEATAT | PGPVTVSPNA | AHLYCIAAAV | VVV TYPVCI |
SLLCLGVKER | PDPSAPASGP | GLSFLAGLSL | TTRHPPYLKL | VISFLFISAA |
VQVE QSYLV | LFCTHASQLH | DHVQGLVLTV | LVSAVLSTPL | WEWVLQRFGK |
KTSAFGIFAM | VPFAI LLAA | VPTAPVAYVV | AFVSGVSIAV | SLLLPWSMLP |
DVVDDFQLQH | RHGPGLETIF | YSSYVF FTK | LSGACALGIS | TLSLEFSGYK |
AGVCKQAEEV | VVTLKVLIGA | VPTCMILAGL | CILMVGS TP | KTPSRDASSR |
LSLRRRTSYS | LA
This product has not yet been referenced specifically in any publications.
"Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis."
"Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets."
"Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae."
"Understanding transport by the major facilitator superfamily (MFS): structures pave the way."
"Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer."
"Active transporters as enzymes: an energetic framework applied to major facilitator superfamily and ABC importer systems."
"Structural Biology of the Major Facilitator Superfamily Transporters."
"Whole genome methylation analyses of schizophrenia patients before and after treatment."
"Structural advances for the major facilitator superfamily (MFS) transporters."
"Ins and outs of major facilitator superfamily antiporters."
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