Slc25a37 (GeneName), Mitoferrin-1 (ProteinName), MFRN1_RAT.
Rat Slc25a37/ Mitoferrin-1 ELISA Kit
Mitochondrial iron transporter 1, Solute carrier family 25 member 37, Mfrn
Natural and recombinant rat Mitoferrin-1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme.
Mitochondrion inner membrane Multi-pass membrane protein
MELRRGGVGS | QAAGRRMDGD | CRDGGCGSKD | AGSEDYENLP | TSASVSTHMT |
AGAMAGILEH | SIMYPVDSVK | TRMQSLNPDP | KARYTSIYGA | LKRIMHTEGF |
WRPLRGLNVM | MMGAGPAHAM | YFACYENMKR | TLNDVFSHQG | NSHLANGIAG |
SMATLLHDAV | MNPAEVVKQR | LQMYNSQHQS | ALSCIRTVWR | TEGLGAFYRS |
YTTQLTMNIP | FQSIHFITYE | FLQEQVNPRR | DYNPQSHIIS | GGLAGALAAA |
ATTPLDVCKT | LLNTQENMAL | SLANVSGRLS | GMANAFRTVY | QLNGLAGYFK |
GIQARVIYQM | PSTAISWSVY | EFFKYFLTKR | QLENRTLY
This product has not yet been referenced specifically in any publications.
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
"Mitoferrin is essential for erythroid iron assimilation."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age."
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
"Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing."
"Identification of SLC25A37 as a major depressive disorder risk gene."
"Distinct iron architecture in SF3B1-mutant myelodysplastic syndrome patients is linked to an SLC25A37 splice variant with a retained intron."
"The mitochondrial transporter family SLC25: identification, properties and physiopathology."
"Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria."
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