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Mfn2 (GeneName), Mitofusin-2 (ProteinName), MFN2_RAT.
Product Name:

Rat Mfn2/ Mitofusin-2 ELISA Kit

Cat.#:

E15285r

Brand:
EIAab®
Regulatory Status:
Alternative:

Mitochondrial transmembrane GTPase FZO1A, Protein HSG, Transmembrane GTPase MFN2, Fzo1a

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Mitofusin-2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Rat Mfn2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Forms homomultimers and heteromultimers with MFN1 (PubMed:14561718). Oligomerization is essential for mitochondrion fusion (Probable). Interacts with VAT1 (PubMed:17105775). Interacts with STOML2; may form heterooligomers (By similarity). Interacts (phosphorylated) with PARK2 (By similarity). Interacts with EIF2AK3.


Function:
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:14561718, PubMed:15322553, PubMed:12589796, PubMed:12598526). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (PubMed:12598526). Plays an important role in the regulation of vascular smooth muscle cell proliferation (PubMed:15322553). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria (By similarity). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.


Subcellular Location:
Mitochondrion outer membrane Multi-pass membrane protein Colocalizes with BAX during apoptosis.


This product has not yet been referenced specifically in any publications.

[1].
"MFN2 point mutations occur in 3.4% of Charcot-Marie-Tooth families. An investigation of 232 Norwegian CMT families."

[2].
"Control of mitochondrial morphology by a human mitofusin."

[3].
"Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study."

[4].
"Genotype-phenotype correlations in Charcot-Marie-Tooth disease type 2 caused by mitofusin 2 mutations."

[5].
"Severe early-onset axonal neuropathy with homozygous and compound heterozygous MFN2 mutations."

[6].
"Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2."

[7].
"Charcot-Marie-Tooth neuropathy type 2A: novel mutations in the mitofusin 2 gene (MFN2)."

[8].
"Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2."

[9].
"Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A."

[10].
"Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity."
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