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首页  >  酶联免疫试剂盒  >  Human MFN2 ELISA Kit
MFN2 (基因名), Mitofusin-2 (蛋白名), MFN2_HUMAN.
产品名称:

Human MFN2/ Mitofusin-2 ELISA Kit
Mitofusin-2

货号:

E15285h

商标:
EIAab®
监管等级:
别名:

Transmembrane GTPase MFN2, CPRP1, KIAA0214

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
35pg/mL
特异性:
Natural and recombinant human Mitofusin-2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Human MFN2 ELISA Kit
规格 & 价格: cart
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Human MFN2 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Forms homomultimers and heteromultimers with MFN1 (By similarity). Oligomerization is essential for mitochondrion fusion (Probable). Interacts with VAT1 (By similarity). Interacts with STOML2; may form heterooligomers (PubMed:17121834). Interacts (phosphorylated) with PARK2 (PubMed:23620051). Interacts with EIF2AK3.


功能:
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:11181170, PubMed:11950885, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:28114303). Overexpression induces the formation of mitochondrial networks (PubMed:28114303). Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) (PubMed:23620051). Is required for PARK2 recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.


亚细胞位置:
Mitochondrion outer membrane Multi-pass membrane protein Colocalizes with BAX during apoptosis.


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