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Mfn1 (GeneName), Mitofusin-1 (ProteinName), MFN1_RAT.
Product Name:

Rat Mfn1/ Mitofusin-1 ELISA Kit

Cat.#:

E15253r

Brand:
EIAab®
Regulatory Status:
Alternative:

Mitochondrial transmembrane GTPase FZO1B, Transmembrane GTPase MFN1, Fzo1b

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Mitofusin-1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Neurosciences
Rat Mfn1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homodimer, also in the absence of bound GTP. Forms higher oligomers in the presence of a transition state GTP analog (By similarity). Forms homomultimers and heteromultimers with MFN2 (PubMed:14561718). Oligomerization is essential for mitochondrion fusion. Component of a high molecular weight multiprotein complex (By similarity). Interacts with VAT1 (PubMed:17105775).


Function:
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:14561718, PubMed:12589796). Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains (By similarity). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:14561718). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:14561718). Has low GTPase activity.


Subcellular Location:
Mitochondrion outer membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Control of mitochondrial morphology by a human mitofusin."

[2].
"Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1."

[3].
"Evaluation of nine candidate genes in patients with normal tension glaucoma: a case control study."

[4].
"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells."

[5].
"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins."

[6].
"MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion."

[7].
"Structures of human mitofusin 1 provide insight into mitochondrial tethering."

[8].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."

[9].
"Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise."

[10].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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