MFGE8 (GeneName), Lactadherin (ProteinName), MFGM_PIG.
Pig MFGE8/ Lactadherin ELISA Kit
MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1, Sperm surface protein SP47, PP47
Natural and recombinant pig Lactadherin
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Membrane Peripheral membrane protein Secreted Cytoplasmic vesicle Secretory vesicle Acrosome membrane Peripheral membrane protein Located in the acrosomal region of zona-pellucida bound sperm.
FSGDFCDSSL | CLNGGTCLLD | QDPQKPFHCL | CPEGFTGLIC | NETEKGPCFP |
NPCHNDAECE | VIDDAHRGDV | FTEYICKCPH | GYTGIHCEII | CNAPLGMETG |
AIADFQISAS | SMHLGFMGLQ | RWAPELARLH | RAGIVNAWTA | SNYDRNPWIQ |
VNLLRRMRVT | GVVTQGASRA | GSAEYMKTFK | VAYSTDGRKF | QFIQGAEESG |
DKIFMGNLDN | SGLKVNLFEV | PLEVQYVRLV | PIICHRGCTL | RFELLGCELS |
GCAEPLGLKD | NTIPNKQITA | SSFYRTWGLS | AFSWYPFYAR | LDNQGKFNAW |
TAQSNSASEW | LQIDLGSQRR | VTGIITQGAR | DFGHIQYVAA | YKVAYSDDGV |
SWTEYRDQGA | LEGKIFPGNL | DNNSHKKNMF | ETPFLTRFVR | ILPVAWHNRI |
This product has not yet been referenced specifically in any publications.
"SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions."
"Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human."
"Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid."
"Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25."
"Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion."
"Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain."
"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."
"Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements."
"p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and DeltaN isoforms."
"Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection."
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