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MFGE8 (GeneName), Lactadherin (ProteinName), MFGM_PIG.
Product Name:

Pig MFGE8/ Lactadherin ELISA Kit

Cat.#:

E2304p

Brand:
EIAab®
Regulatory Status:
Alternative:

MFGM, Milk fat globule-EGF factor 8, MFG-E8, SED1, Sperm surface protein SP47, PP47

Detection Method:
ELISA
Specificity:
Natural and recombinant pig Lactadherin
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Pig MFGE8 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.


Subcellular Location:
Membrane Peripheral membrane protein Secreted Cytoplasmic vesicle Secretory vesicle Acrosome membrane Peripheral membrane protein Located in the acrosomal region of zona-pellucida bound sperm.


This product has not yet been referenced specifically in any publications.

[1].
"SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions."

[2].
"Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human."

[3].
"Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid."

[4].
"Mapping of a newly discovered human gene homologous to the apoptosis associated-murine mammary protein, MFG-E8, to chromosome 15q25."

[5].
"Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion."

[6].
"Cloning and sequence analysis of human breast epithelial antigen BA46 reveals an RGD cell adhesion sequence presented on an epidermal growth factor-like domain."

[7].
"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."

[8].
"Cross-beta spine architecture of fibrils formed by the amyloidogenic segment NFGSVQFV of medin from solid-state NMR and X-ray fiber diffraction measurements."

[9].
"p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and DeltaN isoforms."

[10].
"Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection."
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