MFF (GeneName), Mitochondrial fission factor (ProteinName), MFF_BOVIN.
Bovine MFF/ Mitochondrial fission factor ELISA Kit
Natural and recombinant bovine Mitochondrial fission factor
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homodimer. Interacts with DNM1L.
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Mitochondrion outer membrane Single-pass type IV membrane protein Peroxisome Cytoplasmic vesicle Secretory vesicle Synaptic vesicle
MAEISRIQYE | MEYTEGISQR | MRVPEKLKVA | PPNADLEQGF | QEGVSNASVI |
MQVPERIVVA | GNNEDIPFSR | PADLDLIQST | PFKPLALKTP | PRVLTLSERP |
LDFLDLERPA | PTPQNEEIRA | VGRLKRERSM | SENAVRQNGQ | LVKTDSMYGI |
SNIDAMIEGT | SEDMTVVDAA | SLRRQIIKLN | RRLQLLEEEN | KERAKREMVM |
YSITVAFWLL | NSWLWFRR
This product has not yet been referenced specifically in any publications.
"The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells."
"Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy."
"Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission."
"Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission."
"Potential use of TIA-1, MFF, microRNA-200a-3p, and microRNA-27 as a novel marker for hepatocellular carcinoma."
"Architecture of the human interactome defines protein communities and disease networks."
"Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons."
"Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways."
"Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family."
"Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity."
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