MFAP5 (GeneName), Microfibrillar-associated protein 5 (ProteinName), MFAP5_BOVIN.
Bovine MFAP5/ Microfibrillar-associated protein 5 ELISA Kit
MFAP-5, MP25, Microfibril-associated glycoprotein 2, MAGP-2, MAGP2
Natural and recombinant bovine Microfibrillar-associated protein 5
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with TGFB2 (By similarity). Interacts with BMP2 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:15131124).
May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils.
Secreted Extracellular space Extracellular matrix
MTFFGPKVLL | LLTALIMSSG | RTPLGVSGQR | GDDVTTVTSE | TFTEDPNLVN |
DPATDETVLA | DIQPSTDDLA | SLNDKNTTTE | CRDEKFACTR | LYSVHRPIKQ |
CLHQICFTSS | RRMYVINNEI | CSRLVCKEHE | AMKDELCRQK | AGLPPRRLRR |
SNYFRLPPCD | NVNLQGPSGL |
This product has not yet been referenced specifically in any publications.
"The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region."
"Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)"
"MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections."
"A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2."
"Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer."
"MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer."
"Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics."
"MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM-integrin-Notch signaling axis."
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