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MFAP5 (GeneName), Microfibrillar-associated protein 5 (ProteinName), MFAP5_BOVIN.
Product Name:

Bovine MFAP5/ Microfibrillar-associated protein 5 ELISA Kit

Cat.#:

E11955b

Brand:
EIAab®
Regulatory Status:
Alternative:

MFAP-5, MP25, Microfibril-associated glycoprotein 2, MAGP-2, MAGP2

Detection Method:
ELISA
Assay Type:
Sandwich
Specificity:
Natural and recombinant bovine Microfibrillar-associated protein 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Bovine MFAP5 ELISA Kit
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Bovine MFAP5 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


General Annotation


Sub Unit:
Interacts with TGFB2 (By similarity). Interacts with BMP2 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:15131124).


Function:
May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils.


Subcellular Location:
Secreted Extracellular space Extracellular matrix


This product has not yet been referenced specifically in any publications.

[1].
"The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region."

[2].
"Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25)"

[3].
"MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections."

[4].
"A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2."

[5].
"Microfibril-associate glycoprotein-2 (MAGP-2) promotes angiogenic cell sprouting by blocking notch signaling in endothelial cells."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"MFAP5 promotes tumor progression and bone metastasis by regulating ERK/MMP signaling pathways in breast cancer."

[8].
"MFAP5 and TNNC1: Potential markers for predicting occult cervical lymphatic metastasis and prognosis in early stage tongue cancer."

[9].
"Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics."

[10].
"MAGP2 controls Notch via interactions with RGD binding integrins: Identification of a novel ECM-integrin-Notch signaling axis."
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