Mex3c (GeneName), RNA-binding E3 ubiquitin-protein ligase MEX3C (ProteinName), MEX3C_MOUSE.
Mouse Mex3c/ RNA-binding E3 ubiquitin-protein ligase MEX3C ELISA Kit
RING finger and KH domain-containing protein 2, RING-type E3 ubiquitin transferase MEX3C, Rkhd2
Natural and recombinant mouse RNA-binding E3 ubiquitin-protein ligase MEX3C
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with USP7, which antagonizes the ability to degrade mRNA.
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation.
Nucleus Cytoplasm Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.
MPSGSSAALA | LALAAAPAPL | PQPPPLPPPP | PAGGPELEGD | GLLLRERLAA |
LGLDDPSPAE | PGAPALRAAA | VAAAAAAQCQ | ARRATGLAPE | EPGRLATSET |
AELELEVDEE | EGEEAELDGE | LLEEEELEEA | EEEDRPSLLL | LSPPAATASQ |
TQPIPGGPLG | SVLLPAAGFD | AREAAAAGVL | YGGDDAQGMM | AAMLSHAYGP |
GGGGAAAAAL | NGEQAALLRR | KSVNTTECVP | VPSSEHVAEI | VGRQGCKIKA |
LRAKTNTYIK | TPVRGEEPIF | VVTGRKEDVA | MAKREILSAA | EHFSMIRASR |
NKNGPALGGL | SCSPNLPGQT | TVQVRVPYRV | VGLVVGPKGA | TIKRIQQQTH |
TYIVTPSRDK | EPVFEVTGMP | ENVDRAREEI | EMHIAMRTGN | YIELNEENDF |
HYNGTDVSFE | GGTLGSAWLS | SNPVPPSRAR | MMSNYRNDSS | SSLGSGSTDS |
YFGSNRLADF | SPTSPFSTGN | FWFGDTLPSV | GSEDLTVDSP | AFDSLPTSAQ |
TIWTPFEPVN | PLSGFGSDPS | GNMKTQRRGS | QPSTPRLSPT | FPESIEHPLA |
RRVRSDPPST | GNHVGLPIYI | PAFSNGTNSY | SSSNGGSTSS | SPPESRRKHD |
CVICFENEVI | AALVPCGHNL | FCMECANKIC | EKRTPSCPVC | QTAVTQAIQI |
This product has not yet been referenced specifically in any publications.
"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies."
"The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene."
"DNA sequence and analysis of human chromosome 18."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity."
"MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting."
"A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C."
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