MEX3C (GeneName), RNA-binding E3 ubiquitin-protein ligase MEX3C (ProteinName), MEX3C_HUMAN.
Human MEX3C/ RNA-binding E3 ubiquitin-protein ligase MEX3C ELISA Kit
RING finger and KH domain-containing protein 2, RING finger protein 194, RING-type E3 ubiquitin transferase MEX3C, RKHD2, RNF194, BM-013
Natural and recombinant human RNA-binding E3 ubiquitin-protein ligase MEX3C
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with USP7, which antagonizes the ability to degrade mRNA.
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Cytoplasm Nucleus Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
MPSGSSAALA | LAAAPAPLPQ | PPPPPPPPPP | PLPPPSGGPE | LEGDGLLLRE |
RLAALGLDDP | SPAEPGAPAL | RAPAAAAQGQ | ARRAAELSPE | ERAPPGRPGA |
PEAAELELEE | DEEEGEEAEL | DGDLLEEEEL | EEAEEEDRSS | LLLLSPPAAT |
ASQTQQIPGG | SLGSVLLPAA | RFDAREAAAA | AAAAGVLYGG | DDAQGMMAAM |
LSHAYGPGGC | GAAAAALNGE | QAALLRRKSV | NTTECVPVPS | SEHVAEIVGR |
QGCKIKALRA | KTNTYIKTPV | RGEEPIFVVT | GRKEDVAMAK | REILSAAEHF |
SMIRASRNKN | GPALGGLSCS | PNLPGQTTVQ | VRVPYRVVGL | VVGPKGATIK |
RIQQQTHTYI | VTPSRDKEPV | FEVTGMPENV | DRAREEIEMH | IAMRTGNYIE |
LNEENDFHYN | GTDVSFEGGT | LGSAWLSSNP | VPPSRARMIS | NYRNDSSSSL |
GSGSTDSYFG | SNRLADFSPT | SPFSTGNFWF | GDTLPSVGSE | DLAVDSPAFD |
SLPTSAQTIW | TPFEPVNPLS | GFGSDPSGNM | KTQRRGSQPS | TPRLSPTFPE |
SIEHPLARRV | RSDPPSTGNH | VGLPIYIPAF | SNGTNSYSSS | NGGSTSSSPP |
ESRRKHDCVI | CFENEVIAAL | VPCGHNLFCM | ECANKICEKR | TPSCPVCQTA |
This product has not yet been referenced specifically in any publications.
"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies."
"The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene."
"DNA sequence and analysis of human chromosome 18."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity."
"MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting."
"A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C."
Displaying results : 0
No feedback yet, let's comment.
Product Name *
Size Quantity Price ($) Subtotal 1 ($)
Subtotal 2: $
Size Quantity Price ($)
Do you want to be our agent and get a lower discount?
Please contact us:
Please contact us: