Mettl16 (GeneName), RNA N6-adenosine-methyltransferase METTL16 (ProteinName), MET16_MOUSE.
Mouse Mettl16/ RNA N6-adenosine-methyltransferase METTL16 ELISA Kit
Methyltransferase 10 domain-containing protein, Mett10d, Methyltransferase-like protein 16, N6-adenosine-methyltransferase METTL16, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Natural and recombinant mouse RNA N6-adenosine-methyltransferase METTL16
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MEPCE. Interacts with LARP7.
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:29262316, PubMed:30197299). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (By similarity). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (By similarity). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:29262316, PubMed:30197299). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:29262316). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (By similarity). Also able to bind various lncRNAs (By similarity). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (By similarity) (PubMed:29262316, PubMed:30197299).
MALSKSMHAR | NRYKDKPPDF | AYLASKYPDF | KQHIQINLNG | RVSLNFKDPE |
AVRALTCTLL | REDFGLSID | IPLERLIPTV | PLRLNYIHWV | EDLIGHQDSD |
KTTLRRGIDI | GTGASCIYPL | L GATLNGWY | FLATEVDDMC | FNYAKKNVEQ |
NNLSDLIKVV | KVPQKTLLMD | ALKEESEIVY | DF CMCNPPF | FANQLEAKGV |
NSRNSRRPPP | SSVNTGGITE | IMAEGGELEF | VKRIIHDSLQ | LKK RLRWYS |
CMLGKKCSLA | PLKEELRIQG | VPKVTFTEFC | QGRTMRWALA | WSFYDDVTVP |
SPPS KRRKL | EKPRKPITFV | VLESVMKELS | LKASSLGSET | AEGIVVVTTW |
IEKILTDLKV | QHKRI PCGR | EEVSLFLTAI | ENSWIHLRRK | RRERVRQLRE |
VPRAPEDVIL | ALEERKSTPK | ELSSGQ DVA | HSPQESALCG | LDVPGGEAAA |
DGGHCLSQKL | LCQEETPEAT | EDERDEERGG | MEAMESC KG | SSNGAQDGEA |
SEKGDRLDGA | AGRYLFKCLV | NIKKEAGDAV | VEMHWVEGQN | RDLMNQLC T |
YVRNQILRLV | AS
This product has not yet been referenced specifically in any publications.
"The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention."
"Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs."
"Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA."
"The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"Architecture of the human interactome defines protein communities and disease networks."
"S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1."
"Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
"Panorama of ancient metazoan macromolecular complexes."
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