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首页  >  酶联免疫试剂盒  >  Mouse Mettl16 ELISA Kit
Mettl16 (基因名), RNA N6-adenosine-methyltransferase METTL16 (蛋白名), MET16_MOUSE.
产品名称:

Mouse Mettl16/ RNA N6-adenosine-methyltransferase METTL16 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Methyltransferase 10 domain-containing protein, Mett10d, Methyltransferase-like protein 16, N6-adenosine-methyltransferase METTL16, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

检测方法:
ELISA
特异性:
Natural and recombinant mouse RNA N6-adenosine-methyltransferase METTL16
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Mettl16 ELISA Kit
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Mouse Mettl16 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with MEPCE. Interacts with LARP7.


功能:
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:29262316, PubMed:30197299). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (By similarity). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (By similarity). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression (PubMed:29262316, PubMed:30197299). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:29262316). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (By similarity). Also able to bind various lncRNAs (By similarity). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (By similarity) (PubMed:29262316, PubMed:30197299).


亚细胞位置:
Nucleus


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