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METTL16 (GeneName), RNA N6-adenosine-methyltransferase METTL16 (ProteinName), MET16_CHICK.
Product Name:

Chicken METTL16/ RNA N6-adenosine-methyltransferase METTL16 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Methyltransferase 10 domain-containing protein, METT10D, RCJMB04_28o5, Methyltransferase-like protein 16, N6-adenosine-methyltransferase METTL16, U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase

Detection Method:
ELISA
Specificity:
Natural and recombinant chicken RNA N6-adenosine-methyltransferase METTL16
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Chicken METTL16 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing and/or stability of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, impairing MAT2A expression. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention."

[2].
"Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs."

[3].
"Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA."

[4].
"The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel."

[5].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1."

[8].
"Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation."

[9].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[10].
"Panorama of ancient metazoan macromolecular complexes."
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