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METTL14 (GeneName), N6-adenosine-methyltransferase non-catalytic subunit (ProteinName), MET14_HUMAN.
Product Name:

Human METTL14/ N6-adenosine-methyltransferase non-catalytic subunit ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Methyltransferase-like protein 14, hMETTL14, KIAA1627

Detection Method:
ELISA
Specificity:
Natural and recombinant human N6-adenosine-methyltransferase non-catalytic subunit
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human METTL14 ELISA Kit
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Human METTL14 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase (PubMed:27627798, PubMed:27373337, PubMed:27281194). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:24407421, PubMed:24981863, PubMed:24316715, PubMed:29507755, PubMed:29348140). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:24407421, PubMed:24981863, PubMed:24316715, PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755).


Function:
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation."

[2].
"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

[3].
"Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex."

[4].
"VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation."

[5].
"Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex."

[6].
"Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases."

[7].
"Structural insights into the molecular mechanism of the m(6)A writer complex."

[8].
"N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions."

[9].
"Dynamic m(6)A mRNA methylation directs translational control of heat shock response."

[10].
"Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites."
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