METTL14 (基因名), N6-adenosine-methyltransferase non-catalytic subunit (蛋白名), MET14_HUMAN.
Human METTL14/ N6-adenosine-methyltransferase non-catalytic subunit ELISA Kit
Methyltransferase-like protein 14, hMETTL14, KIAA1627
Natural and recombinant human N6-adenosine-methyltransferase non-catalytic subunit
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase (PubMed:27627798, PubMed:27373337, PubMed:27281194). Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:24407421, PubMed:24981863, PubMed:24316715, PubMed:29507755, PubMed:29348140). The MAC subcomplex is composed of METTL3 and METTL14 (PubMed:24407421, PubMed:24981863, PubMed:24316715, PubMed:29507755). The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755).
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis (PubMed:24316715, PubMed:24407421, PubMed:25719671, PubMed:29348140, PubMed:27373337, PubMed:27281194). In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27627798, PubMed:27373337, PubMed:27281194, PubMed:29348140). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity).
MDSRLQEIRE | RQKLRRQLLA | QQLGAESADS | IGAVLNSKDE | QREIAETRET |
CRASYDTSAP | NAKRKYLDE | GETDEDKMEE | YKDELEMQQD | EENLPYEEEI |
YKDSSTFLKG | TQSLNPHNDY | C QHFVDTGH | RPQNFIRDVG | LADRFEEYPK |
LRELIRLKDE | LIAKSNTPPM | YLQADIEAFD | IR ELTPKFD | VILLEPPLEE |
YYRETGITAN | EKCWTWDDIM | KLEIDEIAAP | RSFIFLWCGS | GEG LDLGRV |
CLRKWGYRRC | EDICWIKTNK | NNPGKTKTLD | PKAVFQRTKE | HCLMGIKGTV |
KRST DGDFI | HANVDIDLII | TEEPEIGNIE | KPVEIFHIIE | HFCLGRRRLH |
LFGRDSTIRP | GWLTV GPTL | TNSNYNAETY | ASYFSAPNSY | LTGCTEEIER |
LRPKSPPPKS | KSDRGGGAPR | GGGRGG TSA | GRGRERNRSN | FRGERGGFRG |
GRGGAHRGGF | PPR
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