Mesp2 (GeneName), Mesoderm posterior protein 2 (ProteinName), MESP2_MOUSE.
Mouse Mesp2/ Mesoderm posterior protein 2 ELISA Kit
Natural and recombinant mouse Mesoderm posterior protein 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates also the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Controls also the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers.
MAQSSPPQSL | QGLVPLGLLP | GLGLGSAIGL | HVSGLVLRFV | RFLPFYATRR |
PSQPAGPARS | TRTTQATAPR | RTRPAPAGGQ | RQSASEREKL | RMRTLARALQ |
ELRRFLPPSV | APAGQSLTKI | ETLRLAIRYI | GHLSALLGLS | EDSLRRRRRR |
SADAAFSHRC | PQCPDGGSPS | QAQMLGPSLG | SAMSSGVSWG | CPPACPGPLI |
SPENLGNRIS | NVDPRVTPPY | CPQIQSPLHQ | SLERAADSSP | WAPPQACPGM |
QMSPEPRNKT | GHWTQSTEPA | ELTKVYQSLS | VSPEPRLSLG | SPLLLPRPSC |
QRLQPQPQPQ | PQWGCWGHDA | EVLSTSEDQG | SSPALQLPVA | SPTPSSGLQL |
SGCPELWQED | LEGPPLNIFY |
This product has not yet been referenced specifically in any publications.
"Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development."
"Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome."
"Mutated MESP2 causes spondylocostal dysostosis in humans."
"Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening."
"Architecture of the human interactome defines protein communities and disease networks."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
"Proteomic analysis of podocyte exosome-enriched fraction from normal human urine."
"Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis."
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