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Mesd (GeneName), LRP chaperone MESD (ProteinName), MESD_RAT.
Product Name:

Rat Mesd/ LRP chaperone MESD ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Mesdc2

Detection Method:
ELISA
Specificity:
Natural and recombinant rat LRP chaperone MESD
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat Mesd ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP4; the interaction promotes glycosylation of LRP4 and its cell-surface expression.


Function:
Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.


Subcellular Location:
Endoplasmic reticulum Released from apoptotic cells and shed photoreceptor outer segments.


This product has not yet been referenced specifically in any publications.

[1].
"Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins."

[2].
"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."

[3].
"Development of a conditional Mesd (mesoderm development) allele for functional analysis of the low-density lipoprotein receptor-related family in defined tissues."

[4].
"Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25)."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity."

[7].
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."

[8].
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."

[9].
"Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis."

[10].
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma."
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