Mertk (GeneName), Tyrosine-protein kinase Mer (ProteinName), MERTK_MOUSE.
Mouse Mertk/ Tyrosine-protein kinase Mer ELISA Kit
Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mer
Natural and recombinant mouse Tyrosine-protein kinase Mer
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner.
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Membrane Single-pass type I membrane protein
MVLAPLLLGL | LLLPALWSGG | TAEKWEETEL | DQLFSGPLPG | RLPVNHRPFS |
APHSSRDQLP | PPQTGRSHPA | HTAAPQVTST | ASKLLPPVAF | NHTIGHIVLS |
EHKNVKFNCS | INIPNTYQET | AGISWWKDGK | ELLGAHHSIT | QFYPDEEGVS |
IIALFSIASV | QRSDNGSYFC | KMKVNNREIV | SDPIYVEVQG | LPYFIKQPES |
VNVTRNTAFN | LTCQAVGPPE | PVNIFWVQNS | SRVNEKPERS | PSVLTVPGLT |
ETAVFSCEAH | NDKGLTVSKG | VHINIKVIPS | PPTEVHILNS | TAHSILVSWV |
PGFDGYSPLQ | NCSIQVKEAD | RLSNGSVMVF | NTSASPHLYE | IQQLQALANY |
SIAVSCRNEI | GWSAVSPWIL | ASTTEGAPSV | APLNITVFLN | ESNNILDIRW |
TKPPIKRQDG | ELVGYRISHV | WESAGTYKEL | SEEVSQNGSW | AQIPVQIHNA |
TCTVRIAAIT | KGGIGPFSEP | VNIIIPEHSK | VDYAPSSTPA | PGNTDSMFII |
LGCFCGFILI | GLILCISLAL | RRRVQETKFG | GAFSEEDSQL | VVNYRAKKSF |
CRRAIELTLQ | SLGVSEELQN | KLEDVVIDRN | LLVLGKVLGE | GEFGSVMEGN |
LKQEDGTSQK | VAVKTMKLDN | FSQREIEEFL | SEAACMKDFN | HPNVIRLLGV |
CIELSSQGIP | KPMVILPFMK | YGDLHTFLLY | SRLNTGPKYI | HLQTLLKFMM |
DIAQGMEYLS | NRNFLHRDLA | ARNCMLRDDM | TVCVADFGLS | KKIYSGDYYR |
QGRIAKMPVK | WIAIESLADR | VYTSKSDVWA | FGVTMWEITT | RGMTPYPGVQ |
NHEMYDYLLH | GHRLKQPEDC | LDELYDIMYS | CWSADPLDRP | TFSVLRLQLE |
KLSESLPDAQ | DKESIIYINT | QLLESCEGIA | NGPSLTGLDM | NIDPDSIIAS |
CTPGAAVSVV | TAEVHENNLR | EERYILNGGN | EEWEDVSSTP | FAAVTPEKDG |
VLPEDRLTKN | GVSWSHHSTL | PLGSPSPDEL | LFVDDSLEDS | EVLM
This product has not yet been referenced specifically in any publications.
"MERTK polymorphisms associated with risk of haematological disorders among Korean SLE patients."
"An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action."
"Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa."
"Cloning and mRNA expression analysis of a novel human protooncogene, c-mer."
"Galectin-3 is a new MerTK-specific eat-me signal."
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