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首页  >  酶联免疫试剂盒  >  Rat Nf2 ELISA Kit
Nf2 (基因名), Merlin (蛋白名), MERL_RAT.
产品名称:

Rat Nf2/ Merlin ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomin

检测方法:
ELISA
特异性:
Natural and recombinant rat Merlin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Rat Nf2 ELISA Kit
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Rat Nf2 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with SLC9A3R1, HGS and AGAP2. Interacts with SGSM3. Interacts (via FERM domain) with MPP1 (By similarity). Interacts with LAYN and WWC1. Interacts with the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1.


功能:
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex Plays a role in lens development and is required for complete fiber cell terminal differentiation, maintenance of cell polarity and separation of the lens vesicle from the corneal epithelium.


亚细胞位置:
Cell membrane Peripheral membrane protein Cytoplasmic side Cell projection Cytoplasm Cytoskeleton Nucleus Colocalizes with MPP1 in non-myelin-forming Schwann cells. Binds with VPRBP in the nucleus. The intramolecular association of the FERM domain with the C-terminal tail promotes nuclear accumulation. The unphosphorylated form accumulates predominantly in the nucleus while the phosphorylated form is largely confined to the non-nuclear fractions (By similarity).


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