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NF2 (基因名), Merlin (蛋白名), MERL_HUMAN.
产品名称:

Human NF2/ Merlin ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, SCH

检测方法:
ELISA
特异性:
Natural and recombinant human Merlin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Human NF2 ELISA Kit
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Human NF2 ELISA Kit
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通用注释


亚单元:
Interacts with SLC9A3R1, HGS and AGAP2. Interacts with LAYN (By similarity). Interacts with SGSM3. Interacts (via FERM domain) with MPP1. Interacts with WWC1. Interacts with the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. The unphosphorylated form interacts (via FERM domain) with VPRBP/DCAF1.


功能:
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.


亚细胞位置:
Isoform 10 Nucleus Cell projection Filopodium membrane Peripheral membrane protein Cytoplasmic side Cell projection Ruffle membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Perinuclear region Cytoplasmic granule Cytoplasm Cytoskeleton In a fibroblastic cell line, isoform 10 is found homogeneously distributed over the entire cell, with a particularly strong staining in ruffling membranes and filopodia.


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