MEPCE (GeneName), 7SK snRNA methylphosphate capping enzyme (ProteinName), MEPCE_HUMAN.
Human MEPCE/ 7SK snRNA methylphosphate capping enzyme ELISA Kit
MePCE, Bicoid-interacting protein 3 homolog, Bin3 homolog, BCDIN3
Natural and recombinant human 7SK snRNA methylphosphate capping enzyme
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, MEPCE/BCDIN3, SART3 proteins and 7SK and U6 snRNAs.
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it.
MIEMAAEKEP | FLVPAPPPPL | KDESGGGGGP | TVPPHQEAAS | GELRGGTERG |
PGRCAPSAGS | PAAAVGRESP | GAAATSSSGP | QAQQHRGGGP | QAQSHGEARL |
SDPPGRAAPP | DVGEERRGGG | GTELGPPAPP | RPRNGYQPHR | PPGGGGGKRR |
NSCNVGGGGG | GFKHPAFKRR | RRVNSDCDSV | LPSNFLLGGN | IFDPLNLNSL |
LDEEVSRTLN | AETPKSSPLP | AKGRDPVEIL | IPKDITDPLS | LNTCTDEGHV |
VLASPLKTGR | KRHRHRGQHH | QQQQAAGGSE | SHPVPPTAPL | TPLLHGEGAS |
QQPRHRGQNR | DAPQPYELNT | AINCRDEVVS | PLPSALQGPS | GSLSAPPAAS |
VISAPPSSSS | RHRKRRRTSS | KSEAGARGGG | QGSKEKGRGS | WGGRHHHHHP |
LPAAGFKKQQ | RKFQYGNYCK | YYGYRNPSCE | DGRLRVLKPE | WFRGRDVLDL |
GCNVGHLTLS | IACKWGPSRM | VGLDIDSRLI | HSARQNIRHY | LSEELRLPPQ |
TLEGDPGAEG | EEGTTTVRKR | SCFPASLTAS | RGPIAAPQVP | LDGADTSVFP |
NNVVFVTGNY | VLDRDDLVEA | QTPEYDVVLC | LSLTKWVHLN | WGDEGLKRMF |
RRIYRHLRPG | GILVLEPQPW | SSYGKRKTLT | ETIYKNYYRI | QLKPEQFSSY |
LTSPDVGFSS | YELVATPHNT | SKGFQRPVYL | FHKARSPSH
This product has not yet been referenced specifically in any publications.
"Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme."
"Identification and characterization of a novel gene encoding a SEREX antigen in chronic myeloid leukaemia."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"Human chromosome 7: DNA sequence and biology."
"The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression."
"Architecture of the human interactome defines protein communities and disease networks."
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."
"Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs."
"Targeting HIV transcription: the quest for a functional cure."
"Intermolecular recognition of the non-coding RNA 7SK and HEXIM protein in perspective."
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