WDR77 (GeneName), Methylosome protein 50 (ProteinName), MEP50_HUMAN.
Human WDR77/ Methylosome protein 50 ELISA Kit
MEP-50, Androgen receptor cofactor p44, WD repeat-containing protein 77, p44/Mep50, MEP50, WD45, HKMT1069, Nbla10071
Natural and recombinant human Methylosome protein 50
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1A, WDR77, PRMT1 and ERH (PubMed:25284789). Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1. Interacts with CHTOP (PubMed:25284789).
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
Nucleus Cytoplasm Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.
MRKETPPPLV | PPAAREWNLP | PNAPACMERQ | LEAARYRSDG | ALLLGASSLS |
GRCWAGSLWL | FKDPCAAPNE | GFCSAGVQTE | AGVADLTWVG | ERGILVASDS |
GAVELWELDE | NETLIVSKFC | KYEHDDIVST | VSVLSSGTQA | VSGSKDICIK |
VWDLAQQVVL | SSYRAHAAQV | TCVAASPHKD | SVFLSCSEDN | RILLWDTRCP |
KPASQIGCSA | PGYLPTSLAW | HPQQSEVFVF | GDENGTVSLV | DTKSTSCVLS |
SAVHSQCVTG | LVFSPHSVPF | LASLSEDCSL | AVLDSSLSEL | FRSQAHRDFV |
RDATWSPLNH | SLLTTVGWDH | QVVHHVVPTE | PLPAPGPASV | TE
This product has not yet been referenced specifically in any publications.
"A novel WD repeat protein component of the methylosome binds Sm proteins."
"5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex."
"Crystal structure of the human PRMT5:MEP50 complex."
"RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity."
"APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process."
"An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
"The expression and function of androgen receptor coactivator p44 and protein arginine methyltransferase 5 in the developing testis and testicular tumors."
"The DNA sequence and biological annotation of human chromosome 1."
"Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro."
"Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."
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