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首页  >  酶联免疫试剂盒  >  Bovine WDR77 ELISA Kit
WDR77 (基因名), Methylosome protein 50 (蛋白名), MEP50_BOVIN.
产品名称:

Bovine WDR77/ Methylosome protein 50 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

MEP-50, WD repeat-containing protein 77, MEP50

检测方法:
ELISA
特异性:
Natural and recombinant bovine Methylosome protein 50
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Epigenetics
Bovine WDR77 ELISA Kit
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Bovine WDR77 ELISA Kit
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产品说明书


通用注释


亚单元:
Component of the methylosome, a 20S complex containing at least PRMT5, CLNS1A, WDR77, PRMT1 and ERH. Directly interacts with PRMT5, as well as with several Sm proteins, including SNRPB and SNRPD2 and, more weakly, SNRPD3 and SNRPE. Forms a compact hetero-octamer with PRMT5, decorating the outer surface of a PRMT5 tetramer. Interacts with SUZ12 and histone H2A/HIST2H2AC, but not with histones H2B, H3 nor H4. Interacts with CTDP1 and LSM11. Interacts with APEX1, AR and NKX3-1. Interacts with CHTOP.


功能:
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.


亚细胞位置:
Nucleus Cytoplasm


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