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Mep1b (基因名), Meprin A subunit beta (蛋白名), MEP1B_MOUSE.
产品名称:

Mouse Mep1b/ Meprin A subunit beta ELISA Kit
美普利亚单位

货号:

E1619m

商标:
EIAab®
监管等级:
别名:

Endopeptidase-2, Meprin B, Mep-1b

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.168ng/mL
特异性:
Natural and recombinant mouse Meprin A subunit beta
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Mouse Mep1b ELISA Kit
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Mouse Mep1b ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homotetramer consisting of disulfide-linked beta subunits, or heterotetramer of two alpha and two beta subunits formed by non-covalent association of two disulfide-linked heterodimers. Interacts with MBL2 through its carbohydrate moiety. This interaction may inhibit its catalytic activity.


功能:
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position (PubMed:11278902). Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Secreted Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.


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