MEOX2 (GeneName), Homeobox protein MOX-2 (ProteinName), MEOX2_HUMAN.
Human MEOX2/ Homeobox protein MOX-2 ELISA Kit
Growth arrest-specific homeobox, Mesenchyme homeobox 2, GAX, MOX2
Natural and recombinant human Homeobox protein MOX-2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with RNF10.
Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
Nucleus Nucleus speckle
MEHPLFGCLR | SPHATAQGLH | PFSQSSLALH | GRSDHMSYPE | LSTSSSSCII |
AGYPNEEGMF | ASQHHRGHHH | HHHHHHHHHH | QQQQHQALQT | NWHLPQMSSP |
PSAARHSLCL | QPDSGGPPEL | GSSPPVLCSN | SSSLGSSTPT | GAACAPGDYG |
RQALSPAEAE | KRSGGKRKSD | SSDSQEGNYK | SEVNSKPRKE | RTAFTKEQIR |
ELEAEFAHHN | YLTRLRRYEI | AVNLDLTERQ | VKVWFQNRRM | KWKRVKGGQQ |
GAAAREKELV | NVKKGTLLPS | ELSGIGAATL | QQTGDSIANE | DSHDSDHSSE |
This product has not yet been referenced specifically in any publications.
"Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."
"Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3."
"Molecular cloning and localization of the human GAX gene to 7p21."
"Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor."
"A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a."
"Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Human chromosome 7: DNA sequence and biology."
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