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MEOX1 (GeneName), Homeobox protein MOX-1 (ProteinName), MEOX1_HUMAN.
Product Name:

Human MEOX1/ Homeobox protein MOX-1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Mesenchyme homeobox 1, MOX1

Detection Method:
ELISA
Specificity:
Natural and recombinant human Homeobox protein MOX-1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cancer
Human MEOX1 ELISA Kit
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Human MEOX1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.


Subcellular Location:
Nucleus Cytoplasm Localizes predominantly in the nucleus.


This product has not yet been referenced specifically in any publications.

[1].
"Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture."

[2].
"Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly."

[3].
"Mutation in MEOX1 gene causes a recessive Klippel-Feil syndrome subtype."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Architecture of the human interactome defines protein communities and disease networks."

[6].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."

[7].
"Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer."

[8].
"Widespread macromolecular interaction perturbations in human genetic disorders."

[9].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[10].
"Systematic identification of pathological lamin A interactors."
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