MEOX1 (GeneName), Homeobox protein MOX-1 (ProteinName), MEOX1_HUMAN.
Human MEOX1/ Homeobox protein MOX-1 ELISA Kit
Mesenchyme homeobox 1, MOX1
Natural and recombinant human Homeobox protein MOX-1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome.
Nucleus Cytoplasm Localizes predominantly in the nucleus.
MDPAASSCMR | SLQPPAPVWG | CLRNPHSEGN | GASGLPHYPP | TPFSFHQKPD |
FLATATAAYP | DFSASCLAAT | PHSLPQEEHI | FTEQHPAFPQ | SPNWHFPVSD |
ARRRPNSGPA | GGSKEMGTSS | LGLVDTTGGP | GDDYGVLGST | ANETEKKSSR |
RRKESSDNQE | NRGKPEGSSK | ARKERTAFTK | EQLRELEAEF | AHHNYLTRLR |
RYEIAVNLDL | SERQVKVWFQ | NRRMKWKRVK | GGQPISPNGQ | DPEDGDSTAS |
This product has not yet been referenced specifically in any publications.
"Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture."
"Mutations in MEOX1, encoding mesenchyme homeobox 1, cause Klippel-Feil anomaly."
"Mutation in MEOX1 gene causes a recessive Klippel-Feil syndrome subtype."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."
"Novel cancer stem cell targets during epithelial to mesenchymal transition in PTEN-deficient trastuzumab-resistant breast cancer."
"Widespread macromolecular interaction perturbations in human genetic disorders."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
"Systematic identification of pathological lamin A interactors."
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