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MEN1 (GeneName), Menin (ProteinName), MEN1_CANFA.
Product Name:

Dog MEN1/ Menin ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant dog Menin
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Dog MEN1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Interacts with JUND.


Function:
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Should routine analysis of the MEN1 gene be performed in all patients with primary hyperparathyroidism under 40 years of age?"

[2].
"Mutation analysis of MEN1, HRPT2, CASR, CDKN1B, and AIP genes in primary hyperparathyroidism patients with features of genetic predisposition."

[3].
"Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas."

[4].
"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."

[5].
"Functional interaction between tumor suppressor menin and activator of S-phase kinase."

[6].
"Menin associates with FANCD2, a protein involved in repair of DNA damage."

[7].
"Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study."

[8].
"The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation."

[9].
"Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling."

[10].
"Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1."
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