MEMO1 (GeneName), Protein MEMO1 (ProteinName), MEMO1_HUMAN.
Human MEMO1/ Protein MEMO1 ELISA Kit
C21orf19-like protein, Hepatitis C virus NS5A-transactivated protein 7, HCV NS5A-transactivated protein 7, Mediator of ErbB2-driven cell motility 1, Mediator of cell motility 1, C2orf4, MEMO, NS5ATP7, CGI-27
Natural and recombinant human Protein MEMO1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with ERBB2 phosphorylated on 'Tyr-1248'.
May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
MSNRVVCREA | SHAGSWYTAS | GPQLNAQLEG | WLSQVQSTKR | PARAIIAPHA |
GYTYCGSCAA | HAYKQVDPSI | TRRIFILGPS | HHVPLSRCAL | SSVDIYRTPL |
YDLRIDQKIY | GELWKTGMFE | RMSLQTDEDE | HSIEMHLPYT | AKAMESHKDE |
FTIIPVLVGA | LSESKEQEFG | KLFSKYLADP | SNLFVVSSDF | CHWGQRFRYS |
YYDESQGEIY | RSIEHLDKMG | MSIIEQLDPV | SFSNYLKKYH | NTICGRHPIG |
VLLNAITELQ | KNGMNMSFSF | LNYAQSSQCR | NWQDSSVSYA | AGALTVH
This product has not yet been referenced specifically in any publications.
"Memo mediates ErbB2-driven cell motility."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts."
"ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."
"Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
"Architecture of the human interactome defines protein communities and disease networks."
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