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Meis2 (GeneName), Homeobox protein Meis2 (ProteinName), MEIS2_MOUSE.
Product Name:

Mouse Meis2/ Homeobox protein Meis2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Meis1-related protein 1, Mrg1, Stra10

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Homeobox protein Meis2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Meis2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Isoform Meis2A interacts with TLX1. Isoform Meis2B interacts with HOXA13 and PBX1 isoform PBX1b. Isoform Meis2D interacts with SP1, SP3 and KLF4. Isoform Meis2D interacts with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform Meis2B is part of a PDX1:PBX1b:MEIS2b complex; Meis2B is recruited by PBX1b and can be replaced by isoform Meis2D in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.


Function:
Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoforms Meis2B and Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription.


Subcellular Location:
Nucleus Cytoplasm Perinuclear region


This product has not yet been referenced specifically in any publications.

[1].
"Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription."

[2].
"Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene."

[3].
"De novo MEIS2 mutation causes syndromic developmental delay with persistent gastro-esophageal reflux."

[4].
"MEIS2 involvement in cardiac development, cleft palate, and intellectual disability."

[5].
"DNA-dependent formation of transcription factor pairs alters their binding specificity."
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