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MEIS1 (GeneName), Homeobox protein Meis1 (ProteinName), MEIS1_HUMAN.
Product Name:

Human MEIS1/ Homeobox protein Meis1 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant human Homeobox protein Meis1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human MEIS1 ELISA Kit
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Human MEIS1 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.


Function:
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels."

[2].
"Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene."

[3].
"Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene."

[4].
"Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice."

[5].
"DNA-dependent formation of transcription factor pairs alters their binding specificity."
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