MEIS1 (GeneName), Homeobox protein Meis1 (ProteinName), MEIS1_HUMAN.
Human MEIS1/ Homeobox protein Meis1 ELISA Kit
Natural and recombinant human Homeobox protein Meis1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with the N-terminal region of PBX1 to form a heterodimer which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterodimers with PBX2. Forms heterotrimers with PBX1 or PBX2 and a number of HOX proteins including HOXA9, HOXD4 and HOXD9 where it acts as a non-DNA-binding partner. Also forms heterotrimers with PBX1 and HOX proteins including HOXD9 and HOXD10 where PBX1 is the non-DNA-binding partner.
Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.
MAQRYDDLPH | YGGMDGVGIP | STMYGDPHAA | RSMQPVHHLN | HGPPLHSHQY |
PHTAHTNAMA | PSMGSSVNDA | LKRDKDAIYG | HPLFPLLALI | FEKCELATCT |
PREPGVAGGD | VCSSESFNED | IAVFAKQIRA | EKPLFSSNPE | LDNLMIQAIQ |
VLRFHLLELE | KVHELCDNFC | HRYISCLKGK | MPIDLVIDDR | EGGSKSDSED |
ITRSANLTDQ | PSWNRDHDDT | ASTRSGGTPG | PSSGGHTSHS | GDNSSEQGDG |
LDNSVASPST | GDDDDPDKDK | KRHKKRGIFP | KVATNIMRAW | LFQHLTHPYP |
SEEQKKQLAQ | DTGLTILQVN | NWFINARRRI | VQPMIDQSNR | AVSQGTPYNP |
DGQPMGGFVM | DGQQHMGIRA | PGPMSGMGMN | MGMEGQWHYM |
This product has not yet been referenced specifically in any publications.
"MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels."
"Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene."
"Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene."
"Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice."
"DNA-dependent formation of transcription factor pairs alters their binding specificity."
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