Meiob (GeneName), Meiosis-specific with OB domain-containing protein (ProteinName), MEIOB_MOUSE.
Mouse Meiob/ Meiosis-specific with OB domain-containing protein ELISA Kit
Protein expressed in male leptotene and zygotene spermatocytes 675, MLZ-675
Natural and recombinant mouse Meiosis-specific with OB domain-containing protein
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Component of a multiprotein complex with RPA2 and SPATA22.
Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro.
Cytoplasm Nucleus Chromosome Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22.
MAKFFALKNF | TALSDLHPNM | ANLKIIGIVI | GKTDVKGFPD | RKNIGSERYT |
FSFTIRDSPC | HFVNVSSWGS | EDYIRSLSES | FRVAECVIIE | NPLIQRKDTE |
REEKFSPATP | SNYKLLLSEN | HSMVKVCSPY | EVDTKLLSLI | HLPVKESRDY |
YSLADIVANG | HSLDGRIINV | LAAVRSVGEP | KYFTTSDRRK | GQRCEVKLFD |
ETEPSFTMTC | WDNESILLAQ | SWMARETVIF | ASDVRINFNK | FQNCMAATVI |
SKTIITVNPD | TPEANILLNY | IRENKETNVA | DEIDSYLKES | VNLNTIVDVY |
TVEQLKVKAL | KSEGKADPFY | GILYAYISTL | NIDDETTKVV | RNRCSSCGYI |
VNEASNTCTI | CNQDSSRLKS | FFLSFDVLVD | LTDHTGTLHS | CSLSGSIAEE |
TLGCTINEFL | TMTSEQKTKL | KWQLLLERSK | IYLKLILSHR | ARGGLKVTIL |
SCKLADPTEA | SRNLARQGHT |
This product has not yet been referenced specifically in any publications.
"MEIOB targets single-strand DNA and is necessary for meiotic recombination."
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."
"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
"Architecture of the human interactome defines protein communities and disease networks."
"A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-κB degradation and cell growth suppression in neuroblastoma."
"A familial study of azoospermic men identifies three novel causative mutations in three new human azoospermia genes."
"The BioPlex Network: A Systematic Exploration of the Human Interactome."
"The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition."
"MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
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