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Meikin (基因名), Meiosis-specific kinetochore protein (蛋白名), MEIKN_MOUSE.
产品名称:

Mouse Meikin/ Meiosis-specific kinetochore protein ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant mouse Meiosis-specific kinetochore protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Meikin ELISA Kit
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Mouse Meikin ELISA Kit
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通用注释


亚单元:
Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores.


功能:
Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.


亚细胞位置:
Chromosome Centromere Chromosome Centromere Kinetochore Localizes at kinetochores in meiosis I but undetectable in meiosis II.


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