MEIKIN (GeneName), Meiosis-specific kinetochore protein (ProteinName), MEIKN_HUMAN.
Human MEIKIN/ Meiosis-specific kinetochore protein ELISA Kit
Natural and recombinant human Meiosis-specific kinetochore protein
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores.
Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.
Chromosome Centromere Chromosome Centromere Kinetochore Localizes at kinetochores in meiosis I but undetectable in meiosis II.
MWPLRVYTRK | KREGQRLNLT | PTPDLGSPAK | AEAPPGSKRK | GKVHGLSKIA |
EKAERSRQGG | SGSGPFSPRL | GVTGEKSLQE | NRSSEDTQDE | KIASLRESVT |
DDLQVDSSSS | NSELVSGLSL | HHGMASSLLS | YSVTDSYAEY | KSFEESFPSP |
ELFRKSDYLD | WECPNLEEHM | QWKNSTLLDT | SKAVAIEKAP | QFSNVSAIFS |
TSSEDYQKCH | RKTVMTVADQ | NVSPKAKCAS | NSESDNAACE | ILLAEKTCPS |
TPEKTKKKKT | NSSTPGKKNR | GLLTSTPSSE | TAGFVIDLSS | VQKASFEELF |
PNVSNYVNSN | EIVPVSSLQE | NSSNEFPANA | SEICCIIRTS | PGTRQVKNKG |
VIVKKKKYSL | PKDTPQDIII | KMA
This product has not yet been referenced specifically in any publications.
"Meikin is a conserved regulator of meiosis-I-specific kinetochore function."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese."
"The DNA sequence and comparative analysis of human chromosome 5."
"Creation of genome-wide protein expression libraries using random activation of gene expression."
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