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Mei4 (GeneName), Meiosis-specific protein MEI4 (ProteinName), MEI4_MOUSE.
Product Name:

Mouse Mei4/ Meiosis-specific protein MEI4 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Meiosis-specific protein MEI4
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Mei4 ELISA Kit
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Mouse Mei4 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with REC114 (PubMed:20551173). Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4 (PubMed:27723721).


Function:
Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:25795304, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).


Subcellular Location:
Chromosome Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:25795304, PubMed:27723721). Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages (PubMed:20551173).


This product has not yet been referenced specifically in any publications.

[1].
"Initiation of meiotic recombination in mammals."

[2].
"Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice."

[3].
"The DNA sequence and analysis of human chromosome 6."
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