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首页  >  酶联免疫试剂盒  >  Mouse Megf10 ELISA Kit
Megf10 (基因名), Multiple epidermal growth factor-like domains protein 10 (蛋白名), MEG10_MOUSE.
产品名称:

Mouse Megf10/ Multiple epidermal growth factor-like domains protein 10 ELISA Kit

货号:

E3888m

商标:
EIAab®
监管等级:
别名:

Multiple EGF-like domains protein 10

检测方法:
ELISA
特异性:
Natural and recombinant mouse Multiple epidermal growth factor-like domains protein 10
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Mouse Megf10 ELISA Kit
规格 & 价格: cart
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Mouse Megf10 ELISA Kit
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产品说明书


通用注释


亚单元:
Homopolymer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11.


功能:
Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation probably through regulation of the notch signaling pathway.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Basolateral cell membrane Single-pass type I membrane protein Cell projection Phagocytic cup Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11 (By similarity). Enriched at the sites of contact with apoptotic thymocyte cells.


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