MEGF10 (GeneName), Multiple epidermal growth factor-like domains protein 10 (ProteinName), MEG10_HUMAN.
Human MEGF10/ Multiple epidermal growth factor-like domains protein 10 ELISA Kit
Multiple EGF-like domains protein 10, KIAA1780
Natural and recombinant human Multiple epidermal growth factor-like domains protein 10
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Homopolymer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11.
Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation probably through regulation of the notch signaling pathway.
Cell membrane Single-pass type I membrane protein Basolateral cell membrane Single-pass type I membrane protein Cell projection Phagocytic cup Enriched at the sites of contact with apoptotic thymocyte cells (By similarity). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11.
MVISLNSCLS | FICLLLCHWI | GTASPLNLED | PNVCSHWESY | SVTVQESYPH |
PFDQIYYTSC | TDILNWFKCT | RHRVSYRTAY | RHGEKTMYRR | KSQCCPGFYE |
SGEMCVPHCA | DKCVHGRCIA | PNTCQCEPGW | GGTNCSSACD | GDHWGPHCTS |
RCQCKNGALC | NPITGACHCA | AGFRGWRCED | RCEQGTYGND | CHQRCQCQNG |
ATCDHVTGEC | RCPPGYTGAF | CEDLCPPGKH | GPQCEQRCPC | QNGGVCHHVT |
GECSCPSGWM | GTVCGQPCPE | GRFGKNCSQE | CQCHNGGTCD | AATGQCHCSP |
GYTGERCQDE | CPVGTYGVLC | AETCQCVNGG | KCYHVSGACL | CEAGFAGERC |
EARLCPEGLY | GIKCDKRCPC | HLENTHSCHP | MSGECACKPG | WSGLYCNETC |
SPGFYGEACQ | QICSCQNGAD | CDSVTGKCTC | APGFKGIDCS | TPCPLGTYGI |
NCSSRCGCKN | DAVCSPVDGS | CTCKAGWHGV | DCSIRCPSGT | WGFGCNLTCQ |
CLNGGACNTL | DGTCTCAPGW | RGEKCELPCQ | DGTYGLNCAE | RCDCSHADGC |
HPTTGHCRCL | PGWSGVHCDS | VCAEGRWGPN | CSLPCYCKNG | ASCSPDDGIC |
ECAPGFRGTT | CQRICSPGFY | GHRCSQTCPQ | CVHSSGPCHH | ITGLCDCLPG |
FTGALCNEVC | PSGRFGKNCA | GICTCTNNGT | CNPIDRSCQC | YPGWIGSDCS |
QPCPPAHWGP | NCIHTCNCHN | GAFCSAYDGE | CKCTPGWTGL | YCTQRCPLGF |
YGKDCALICQ | CQNGADCDHI | SGQCTCRTGF | MGRHCEQKCP | SGTYGYGCRQ |
ICDCLNNSTC | DHITGTCYCS | PGWKGARCDQ | AGVIIVGNLN | SLSRTSTALP |
ADSYQIGAIA | GIIILVLVVL | FLLALFIIYR | HKQKGKESSM | PAVTYTPAMR |
VVNADYTISG | TLPHSNGGNA | NSHYFTNPSY | HTLTQCATSP | HVNNRDRMTV |
TKSKNNQLFV | NLKNVNPGKR | GPVGDCTGTL | PADWKHGGYL | NELGAFGLDR |
SYMGKSLKDL | GKNSEYNSSN | CSLSSSENPY | ATIKDPPVLI | PKSSECGYVE |
MKSPARRDSP | YAEINNSTSA | NRNVYEVEPT | VSVVQGVFSN | NGRLSQDPYD |
LPKNSHIPCH | YDLLPVRDSS | SSPKQEDSGG | SSSNSSSSSE |
This product has not yet been referenced specifically in any publications.
"The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern."
"Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
"Consequences of MEGF10 deficiency on myoblast function and Notch1 interactions."
"Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes."
"Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy."
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