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MEGF10 (基因名), Multiple epidermal growth factor-like domains protein 10 (蛋白名), MEG10_HUMAN.
产品名称:

Human MEGF10/ Multiple epidermal growth factor-like domains protein 10 ELISA Kit

货号:

E3888h

商标:
EIAab®
监管等级:
别名:

Multiple EGF-like domains protein 10, KIAA1780

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.145ng/mL
特异性:
Natural and recombinant human Multiple epidermal growth factor-like domains protein 10
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Human MEGF10 ELISA Kit
规格 & 价格: cart
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Human MEGF10 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homopolymer (Probable). Interacts with GULP1 and ABCA1. Interacts with AP2M1. Does not interact with MEGF11.


功能:
Membrane receptor involved in phagocytosis by macrophages of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. May play role in cell adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation probably through regulation of the notch signaling pathway.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Basolateral cell membrane Single-pass type I membrane protein Cell projection Phagocytic cup Enriched at the sites of contact with apoptotic thymocyte cells (By similarity). Forms an irregular, mosaic-like adhesion pattern in region of the cell surface that becomes firmely fixed to the substrate. Expressed at the cell surface in clusters around cell corpses during engulfment. During the engulfment of apoptotic thymocytes, recruited at the bottom of the forming phagocytic cup. Colocalizes with ABCA1 in absence of any phagocytic challenge. Does not localize within lamellipodia. Does not localize with MEGF11.


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